--中国科学院遗传与发育生物学研究所

姓　　名：	武照伐
职　　称：	研究员
职　　务：
电话/传真：	86-10-64801204
电子邮件：	wuzhaofa@genetics.ac.cn
实验室主页：
研究方向：	神经通讯与脑功能

简历介绍：

武照伐，博士，研究员，博士生导师

2013年获西北农林科技大学学士学位；2019年获北京大学博士学位（导师：李毓龙教授）；2019-2023年先后获勃林格殷格翰博士后基金、CLS杰出博士后基金，在北京大学从事博士后研究（合作导师：李毓龙教授和‪Bastian Hengerer教授）。‬2023年10月加入中国科学院遗传与发育生物学研究所，2024年获基金委“优秀青年科学基金项目”支持。2023年入选北京市“青年人才托举工程”，2024年获朝阳区“凤凰计划”高层次人才认定。‬‬‬‬‬‬‬

研究领域：

研究方向介绍：

大脑作为生物体内结构最复杂且功能最强大的器官，拥有近860亿个神经元，每个神经元能与其它神经元或靶细胞形成多达10000个连接点，从而构成一个庞大的互连网络。工具对研究复杂的大脑至关重要；如何开发和运用新的工具，从而为脑科学的研究带来新的突破是领域内的重大挑战。

我们致力于结合荧光探针技术开发、活体成像、光遗传学/基因编辑操控和化学生物学手段解析大脑细胞间的通讯机制与脑功能。具体研究内容包括：重要神经代谢分子（核苷和脂类）的检测及其在生理（睡眠、情绪等）及病理（癫痫、中风等）过程的功能；大脑中不同细胞类型的能量代谢规律和调控机制；神经-肿瘤-免疫之间的通讯。

课题组目前招收副研究员、助理研究员、博士后（特别科研助理）、博士生和客座研究生。欢迎对脑科学感兴趣的有志青年加入（email: wuzhaofa@genetics.ac.cn）。

社会任职：

获奖及荣誉：

承担科研项目情况：

代表论著：

代表性论文（*Corresponding author; #equal contribution）：

1. Wei, Q.# Bai, Z.#, Wang, L.#, ... Li, Y.*, Wu, Z.*, & Wang, J.* (2025). A high-performance fluorescent sensor spatiotemporally reveals cell-type specific regulation of intracellular adenosine in vivo. Nature Communications

2. Wu, Z.#, Cui, Y.#, Wang, H.#, …, Xu, M., Luo, M.* & Li, Y.* (2023), Neuronal activity-induced, ENT-dependent, somatodendritic adenosine release revealed by a GRAB sensor. PNAS, 120(14), e2212387120.

3. Wu, Z.*, He, K., Chen, Y., …, Du, J., Jing, M., & Li, Y.* (2022). A sensitive GRAB sensor for detecting extracellular ATP in vitro and in vivo. Neuron, 110, 770-782 e775.

—Selected as the “Best of Neuron 2021-2022”.

4. Peng, W.#, Wu, Z.#, Kun, S.#, Zhang, S., Li, Y. & Min, X.* (2020). Regulation of sleep homeostasis mediator adenosine by basal forebrain glutamatergic neurons. Science, 369, 1208.

—Highlights by Whalley K., Nature Reviews Neuroscience. 2020 Nov;21(11):593-593.

5. Wu, Z., Lin, D., & Li, Y.* (2022), Pushing the frontiers: tools for monitoring neurotransmitters and neuromodulators. Nature Reviews Neuroscience, 23, 257–274.

6. Wu, Z.*, & Li, Y.* (2020). New frontiers in probing the dynamics of purinergic transmitters in vivo. Neuroscience Research, 35-43. (Cover).

7. Wu, Z.#, Feng, J.#, Jing, M., & Li, Y.* (2019). G protein-assisted optimization of GPCR-activation based (GRAB) sensors. Neural Imaging and Sensing 2019, vol. 10865, p. 108650N. International Society for Optics and Photonics.

8. Zhou, X.#, He, Y.#, Xu, T.#, Wu, Z.#, Guo, W., Xu, X., ... & Chen, J. F.* (2024). 40 Hz light flickering promotes sleep through cortical adenosine signaling. Cell Research, 1-18.

其它论文：

9. Xin, Q.#, Wang, J.#, …, Wu, Z, …, Hu, H.* (2025). Neuron-astrocyte coupling in lateral habenula mediates depressive-like behaviors. Cell.

10. Park, G.#, Lee, G.#, …, Wu, Z., Li, Y., & Choi M.* (2025). Glia-like taste cells mediate an intercellular mode of peripheral sweet adaptation. Cell, 188(1), 141-156

11. Zhang, Z.#, Wang, Y.#, ... Wu, Z., & Qin, W.* (2025). Spatiotemporally-resolved mapping of extracellular proteomes via in vivo-compatible TyroID. Nature Communications, 16, 2553

12. Guo, Q. #, Hou, T.#, Xie, W.#, ... Wu, Z., … & Wang, S.* (2024). Calcium Homeostasis Modulator 2 Constitutes an ATP-regulation Pore in Mitochondria. bioRxiv, 2024-09.

13. Li, H., Zhao, Y., …, Wu, Z., Li, Y., & Luo, M.* (2024). Astrocytes release ATP/ADP and glutamate in flashes via vesicular exocytosis. Molecular Psychiatry, 1-15.

14. Umpierre, A. D.#, Li, B.#, …, Wu, Z., ... & Wu, L.* (2024). Microglial P2Y6 calcium signaling promotes phagocytosis and shapes neuroimmune responses in epileptogenesis. Neuron, 112(12), 1959-1977.

15. Chen, Y.#, Luan, P.#, Liu, J.#, …, Wu, Z., & Jing, M.* (2024). Spatiotemporally selective astrocytic ATP dynamics encode injury information sensed by microglia following brain injury in mice. Nature Neuroscience, 1-12.

16. Berki, P.#, Cserép, C.#, Környei, Z.#, …, Wu, Z., ... & Dénes, Á.* (2024). Microglia contribute to neuronal synchrony despite endogenous ATP-related phenotypic transformation in acute mouse brain slices. Nature Communications, 15(1), 5402.

17. Roy, K.#, Zhou, X.#, Otani, R.#, Yuan, P. C.#, …, Wu, Z., ... & Lazarus, M.* (2024). Optochemical control of slow-wave sleep in the nucleus accumbens of male mice by a photoactivatable allosteric modulator of adenosine A2A receptors. Nature Communications, 15(1), 3661.

18. Bayazitov, I. T., Teubner, B. J., Feng, F., Wu, Z., Li, Y., Blundon, J. A., & Zakharenko, S.* (2024). Sound-evoked adenosine release in cooperation with neuromodulatory circuits permits auditory cortical plasticity and perceptual learning. Cell Reports, 43(2).

19. Ji, E., Zhang, Y., Li, Z., Wei, L., Wu, Z., Li, Y., Yu, X.*, & Song, T. J.* (2024). The Chemokine CCL2 Promotes Excitatory Synaptic Transmission in Hippocampal Neurons via GluA1 Subunit Trafficking. Neuroscience Bulletin, 1-18.

20. Peng, W.#*, Liu, X.#, Ma, G.#, Wu, Z., … Zhang, S.*, & Min, X.* (2023). Adenosine-independent regulation of the sleep–wake cycle by astrocyte activity. Cell Discovery, 9(1), 16.

21. Li, X., Li, Y., Zhou, Y., …, Wu, Z., ... & Dai, Q.* (2023). Real-time denoising of fluorescence time-lapse imaging enables high-sensitivity observations of biological dynamics beyond the shot-noise limit. Nature Biotechnology, 41, 282–292.

22. Hatashita, Y., Wu, Z., …, & Inoue, T.* (2023). Spontaneous and multifaceted ATP release from astrocytes at the scale of hundreds of synapses. Glia, 71(9), 2250-2265.

23. Lin, R.#*, Zhou, Y.#, Yan, T.#, Wang, R.#, Li, H., Wu, Z., ... & Luo, M.* (2022). Directed evolution of adeno-associated virus for efficient gene delivery to microglia. Nature Methods, 1-10.

24. Pittolo, S., Yokoyama, S., Willoughby, D., ... Wu, Z., … & Poskanzer, K.* (2022). Dopamine Activates Astrocytes in Prefrontal Cortex via α1-Adrenergic Receptors. Cell Reports, 40.

25. Roberts, B., Lambert, E., Livesey, J., Wu, Z., Li, Y. & Cragg, S.* (2022). Dopamine release in nucleus accumbens is under tonic inhibition by adenosine A1 receptors regulated by astrocytic ENT1 and dysregulated by ethanol. The Journal of Neuroscience, 42, 1738-1751.

26. Lu, C.#, Ren, J.#, Mo J., …, Wu, Z., Li, Y., Gao, T., Cao, X.* (2022). Glucocorticoid receptor-dependent astrocytes mediate stress vulnerability. Biological Psychiatry, 92(3), 204-215.

27. Dai, R., Yu, T., Weng, D., Li, H., Cui, Y., Wu, Z., ... & Luo, M.* (2022). A neuropsin-based optogenetic tool for precise control of Gq signaling. Sci. China Life Sci., 1-14.

28. Qian, C., Wu, Z.#, Sun, R.#, …, & Li, Y.* (2021). Localization, proteomics, and metabolite profiling reveal a putative vesicular transporter for UDP-glucose. eLife, 10, e65417.

29. Wang, Q.#, Kong, Y.#, Wu, D. Y., ..., Wu, Z., Li, Y., Yang, J.*, & Gao, T.* (2021). Impaired calcium signaling in astrocytes modulates autism spectrum disorder-like behaviors in mice. Nature Communications, 12(1), 1-13.

30. Feng, J., Zhang, C., Lischinsky, J. E., …, Wu, Z., ... Lin, D., Du, J., & Li, Y.* (2019). A genetically encoded fluorescent sensor for rapid and specific in vivo detection of norepinephrine. Neuron, 102(4), 745-761.

31. Yu, H., Zhao, T., Liu, S., Wu, Q., Johnson, O., Wu, Z., …, Lei, X., Luo, W.* & Li, Y.* (2019). MRGPRX4 is a bile acid receptor for human cholestatic itch. eLife, 8, e48431.