--中国科学院遗传与发育生物学研究所

姓　　名：	李磊
职　　称：	研究员
职　　务：
电话/传真：	86-10-64806908
电子邮件：	leili@genetics.ac.cn
实验室主页：
研究方向：	植物免疫及大豆抗病

简历介绍：

李磊，博士，研究员，博士生导师

李磊，2010年，西北农林科技大学学士，2015年，中国科学院遗传与发育生物学研究所博士，2016-2021年于德国马普发育生物学研究所进行博士后研究，先后获得必和必拓奖（BHBP Fellowship）、EMBO奖（EMBO Fellowship）、人类前沿科学奖（HFSP Fellowship）和国家自然科学奖二等奖（第四完成人）等。实验室长期致力于植物与微生物互作及植物免疫信号转导方面的研究。

研究领域：

1. 植物免疫信号转导

免疫激发子激活植物多种免疫事件，其中包括钙离子、活性氧等。课题组通过鉴定植物内源及病原菌免疫激发子，解析植物受体感受免疫激发子的机制，重点研究下游钙信号调控包括细胞死亡在内的免疫分子机制。

2.根部免疫时空特异性

植物根部免疫信号调控机制具有很强的时空特异性，课题组通过拟南芥和大豆与不同根部病原菌互作的模式，解析植物根部免疫同叶片免疫反应的异同，研究根部不同组织细胞类型响应病原菌侵染的细胞时空异质性，揭示调控细胞免疫调控异质性的分子基础。

3. 大豆抗性基因挖掘

课题组通过遗传学、基因组学等手段定位并克隆大豆重要病害根腐病、锈病等病害的抗性基因，研究大豆抗病基因的遗传进化机制，应用于大豆抗性性状的遗传改良和分子育种。

社会任职：

获奖及荣誉：

承担科研项目情况：

代表论著：

Li, L.^#, Liu, J., and Zhou, J.M.^# (2024). From molecule to cell: the expanding frontiers of plant immunity. J. Genet. Genomics 51, 680–690. (^#co-corresponding authors).

Chen, J.^*, Li, L.^*, Kim, J.H., Neuhäuser, B., Wang, M., Thelen, M., Hilleary, R., Chi, Y., Wei, L., Venkataramani, K., et al. (2023). Small proteins modulate ion-channel-like ACD6 to regulate immunity in Arabidopsis thaliana. Mol. Cell 83, 4386-4397.e9. (^*co-first authors).

Li, L. (2022). My journey studying plant immunity. Cell Host Microbe 30, 463–465.

Schulze, S., Yu, L., Hua, C., Zhang, L., Kolb, D., Weber, H., Ehinger, A., Saile, S.C., Stahl, M., Franz-Wachtel, M., Li, L., et al. (2022). The Arabidopsis TIR-NBS-LRR protein CSA1 guards BAK1-BIR3 homeostasis and mediates convergence of pattern- and effector-induced immune responses. Cell Host Microbe 30, 1717-1731.e6.

Li, L., and Weigel, D. (2021). One hundred years of hybrid necrosis: Hybrid autoimmunity as a window into the mechanisms and evolution of plant-pathogen interactions. Annu. Rev. Phytopathol. 59, 213–237.

Cambiagno, D.A., Giudicatti, A.J., Arce, A.L., Gagliardi, D., Li, L., Yuan, W., Lundberg, D.S., Weigel, D., and Manavella, P.A. (2021). HASTY modulates miRNA biogenesis by linking pri-miRNA transcription and processing. Mol. Plant 14, 426–439.

Li, L., Habring, A., Wang, K., Weigel, D. (2020). Oligomerization of NLR immune receptor RPP7 triggered by atypical resistance protein RPW8/HR. Cell Host Microbe 27, 405-417.

Pramoj, P., Lundberg, D., Weigel, D., Li, L., (2020). Blue native polyacrylamide gel electrophoresis (BN‐PAGE) for the analysis of protein oligomers in plants. Current Protocol in Plant Biology 5, e20107. doi: 10.1002/cppb.20107.

Wang, W., Yang, J., Zhang, J., Liu, Y.-X., Tian, C., Qu, B., Gao, C., Xin, P., Cheng, S., Zhang, W., Miao, P., Li, L., Zhang, X., Chu, J., Zuo, J., Li, J., Bai, Y., Lei, X., Zhou, J.M. (2020). An Arabidopsis secondary metabolite directly targets expression of the bacterial Type III secretion system to inhibit bacterial virulence. Cell Host Microbe 27, 601–613.e7.

Wang, J., Grubb, L.E., Wang, J., Liang, X., Li, L., Gao, C., Ma, M., Feng, F., Li, M., Li, L., Zhang, X., Yu, F., Xie, Q., Chen, S., Zipfel, C., Monaghan, J., Zhou, J.M. (2018). A Regulatory Module Controlling Homeostasis of a Plant Immune Kinase. Molecular Cell 69, 493–504.e6.

Zhu, W., Zaidem, M., Van de Weyer, A.L., Gutaker, R.M., Chae, E., Kim, S.T., Bemm, F., Li, L., Todesco, M., Schwab, R., Unger, F., Beham, M.J., Demar, M., Weigel, D. (2018). Modulation of ACD6 dependent hyperimmunity by natural alleles of an Arabidopsis thaliana NLR resistance gene. PLoS Genetics 14, e1007628.

Li, L.^*,#, Kim, P.^*, Yu, L.^*, Cai, G., Chen, S., Alfano, J.R. and Zhou, J.M.^# (2016) Activation-dependent destruction of a co-receptor by a pseudomonas syringae effector dampens plant immunity. Cell Host Microbe 20, 504-514. (^#co-corresponding authors, ^*co-first authors).

Li, L., Yu, Y., Zhou, Z., and Zhou, J.M. (2016). Plant pattern-recognition receptors controlling innate immunity. Science China Life Sciences 59,878-888.

Liang, X.^*, Ding, P.^*, Lian, K., Wang, J., Ma, M., Li, L., Li, L., Li, M., Zhang, X., Chen, S., Zhang, Y.^#, and Zhou, J.M.^# (2016). Arabidopsis heterotrimeric G proteins directly regulate FLS2-mediated immunity. eLife 10.7554/eLife.13568.

Yang, H., Mu, J., Chen, L., Feng, J., Hu, J., Li, L., Zhou, J.M., and Zuo, J. (2015). S-nitrosylation positively regulates ascorbate peroxidase activity during plant stress responses. Plant Physiology 167, 1604-1615.

Li, L.^*, Li, M.^*, Yu, L., Zhou, Z., Liang, X., Liu, Z., Cai, G., Gao, L., Zhang, X., Wang, Y., Chen, S., and Zhou, J.M. (2014). The FLS2-associated kinase BIK1 directly phosphorylates the NADPH oxidase RbohD to control plant immunity. Cell Host Microbe 15, 329-338 (^*co-first authors).

Sun, Y.^*, Li, L.^*, Macho, A.P., Han, Z., Hu, Z., Zipfel, C., Zhou, J.M.^#, and Chai, J.^# (2013). Structural basis for flg22-induced activation of the Arabidopsis FLS2-BAK1 immune complex. Science 342, 624-628 (^*co-first authors).