--中国科学院遗传与发育生物学研究所

姓　　名：	艾有为
职　　称：	研究员
职　　务：
电话/传真：
电子邮件：	aiyouwei@genetics.ac.cn
实验室主页：
研究方向：	细胞死亡的机制与药物干预

简历介绍：

艾有为，博士，研究员，博士生导师

2012与2016年获东北林大学士与博士学位，博导马建章院士。2014-2021年在北生所进行博士/博后训练，师从王晓东院士研究细胞死亡机制与药物开发。2018年获博新计划支持，2021年加入遗传发育所，2024年获基金委“优秀青年科学基金”支持。

研究领域：

细胞死亡与癌症、炎性损伤、甚至个体死亡息息相关。

本课题组综合生物、化学、医学等多学科知识，通过全基因组CRISPR-Cas9筛选、小分子化合物筛选、多组学分析、分子生化等手段，解析细胞死亡、机体损伤修复、器官衰退与个体死亡的机制，并开发药物进行功能干预。具体研究内容包括：

1.解析细胞死亡的机制与相关细胞生物学新规律;

2.发明小分子药物治疗癌症、外周与中枢炎症性疾病;

3.探究器官衰退与个体自然死亡的规律，并进行药物干预。

本课题组常年招收硕博生、博士后、工作人员。诚挚欢迎有志将生命科学研究当作毕生事业、有志在生命科学研究领域做出“不枉此生”的科研工作的伙伴，加入我们的队伍！！！

社会任职：

获奖及荣誉：

承担科研项目情况：

代表论著：

Publications since 2021 (# First author; * Corresponding author):

1) Qiulin Zhang#, Haiwen Lin#, Jiafan Yuan#, ShiPeng Zhang#, Haotian Wang#, Hanjie Hu, Jingyi Wang, Xiaofei Wang, Zhaofa Wu, ShiChao Lu*, Youwei Ai*, Bo Yan*. Discovery of 2-Chloro-pyrrolo [2, 3-d] pyrimidin-4-one Derivatives as Protein Disulfide Isomerase Inhibitors with a Novel Allosteric-Covalent Binding Mode and Anti-Glioblastoma Activity. (2026), Journal of Medicinal Chemistry, 12, 69(3):3148-3175, doi: 10.1021/acs.jmedchem.5c03058.

2) Buhao Deng#, Jingyi Wang#, Tingyun Yang#, Zhao Deng#, Jiafan Yuan, Bohan Zhang, Zhen Zhou, Fang Chen, Lu Fang, Chengzhi Liang, Bo Yan*, Youwei Ai*. TNF and IFNγ-induced cell death requires IRF1 and ELAVL1 to promote CASP8 expression. (2024), Journal of Cell Biology, 223 (3), e202305026.

---Commented by James E. Vince (The Walter and Eliza Hall Institute of Medical Research) in Journal of Cell Biology: IFNγ: Priming for death.

3) Youwei Ai, Yutong Meng, Bo Yan, Qinyi Zhou, Xiaodong Wang*. The biochemical pathways of apoptotic, necroptotic, pyroptotic, and ferroptotic cell death. (2024), Molecular Cell, 84 (1), 170-179. (Invited Review)

4) Bo Yan#, Zhangcheng Ding, Wenbin Zhang, Gaihong Cai, Hui Han, Yan Ma, Yang Cao, Jiawen Wang, She Chen, Youwei Ai*. Multiple PDE3A modulators act as molecular glues promoting PDE3A-SLFN12 interaction and induce SLFN12 dephosphorylation and cell death. (2022), Cell Chemical Biology 29 (6), 958-969.e5

---Commented by Heidi Greulich (Broad Institute) in Cell Chemical Biology: A complex puzzle: Regulation of SLFN12 RNase activity by phosphorylation.

Selective publications before 2021:

1) Bo Yan#*, Youwei Ai#*, Qi Sun, Yan Ma, Yang Cao, Jiawen Wang, Zhiyuan Zhang, Xiaodong Wang. Membrane damage during ferroptosis is caused by oxidation of phospholipids catalyzed by the oxidoreductases POR and CYB5R1. (2021). Molecular Cell 81 (2), 355-369. e10 (Lead Contact)

---Recommended in Faculty Opinions (F1000Prime) (10.3410/f.739220181.793581481)

---Highlighted in Nature Chemical Biology.

---Highly cited paper.

2) Youwei Ai*#, Haibing He, Peihao Chen, Bo Yan, Wenbin Zhang, Zhangcheng Ding, Dianrong Li, Jie Chen, Yan Ma, Yang Cao, Jie Zhu, Jiaojiao Li, Jinjie Ou, Shan Du, Xiaodong Wang, Jianzhang Ma*, Shuanhu Gao*, Xiangbing Qi*. An alkaloid initiates phosphodiesterase 3A–schlafen 12 dependent apoptosis without affecting the phosphodiesterase activity. (2020). Nature communications 11 (1), 1-10 (Lead Contact)

3) Dianrong Li#, Youwei Ai#, Jia Guo, Baijun Dong, Lin Li, Gaihong Cai, She Chen, Dan Xu, Fengchao Wang, Xiaodong Wang*. Casein kinase 1G2 suppresses necroptosis-promoted testis aging by inhibiting receptor-Interacting kinase 3.(2020). eLife 9, e61564 (Co-first Author)