--中国科学院遗传与发育生物学研究所

姓　　名：	李红菊
职　　称：	研究员
职　　务：
电话/传真：	010-64806901
电子邮件：	hjli@genetics.ac.cn
实验室主页：
研究方向：	植物发育生物学

简历介绍：

李红菊，博士，研究员，博士生导师，课题组组长

2004年获河北师范大学学士学位，2010年获中国科学院遗传发育所博士学位。2010年留所工作，先后任助理研究员、副研究员、研究员。获 “国家优秀青年基金”“国家杰出青年基金”资助，入选中国科学院青促会优秀会员，获“卫志明青年创新奖”、“益海嘉里优秀导师”奖。任Seed Biology、JIPB、Originality编委、中国植物学会理事、植物结构与生殖生物学专业委员会主任。

研究领域：

课题组主要研究植物有性生殖发育的分子调控，以模式植物拟南芥、水稻和豆科植物为材料，解析花发育、传粉受精及种子发育的分子调控机理，以及发育程序与环境的互作机制。

1.挖掘关键基因，探究其在单双子叶植物生殖效率和杂交育种中的应用，探索杂交育种技术新策略，以促进种间优良基因重组，创制新物种和新种质，拓展杂种优势利用范围。

2.解析种子发育的分子调控机理，建立种子改良、单倍体诱导和无融合生殖技术体系，服务杂交育种和制种。

3.解析植物生殖发育与环境之间的互作机制，探索环境智能型植物新理论。

社会任职：

获奖及荣誉：

承担科研项目情况：

代表论著：

代表论著

(*Co-first author; #Co-corresponding author)

1. Liu HR, Li HJ (2026) The stem cell mRNA gatekeeper: from nuclear sequestration to cell wall remodeling. Seed Biology 5: e002.

2. Yang YL, Ding XY, Chen S-Y, Chang S, Yang WC#, Li HJ# (2025) Knockout of a cytokinin oxidase/dehydrogenase boosts soybean yield. Plant Communications 16:101678.

3. Chen S-Y, Li HJ#, Yang WC# (2025) How microspores are reprogrammed into embryos. Seed Biology 4: e021.

4. Li X*, Liu RY*, Chen SY*, Weng XC*, Shan HY*, Sun HR*, Li SX*, Luo M, Smith SM, Li JY, Tian CH#, Liu HT#, Zhu Y#, Dong Y#, Kong HZ#, Li HJ#, Wang B# (2025) Comprehensive overview of plant development: Morphogenesis above ground. Innovation Life 3: 100172.

5. Jia SG, Guo LN, Wang XF, Wang DL, Chen D#, Yang WC#, Li HJ# (2025) Keel petal fusion in soybean: anatomical insights and transcriptomic identification of candidate regulators. Agronomy 15: 1971.

6. Chang S*, Ali I*, Zhou PM*, Cheng HS, Liang X, Wu HM, Shi DQ, Li HJ#, Yang WC# (2025) Kinesins control male germ unit assembly for sperm delivery in Arabidopsis. Nature Plants 11: 1798-1809.

7. Wang J, Wang K, Yang WC#, Li HJ# (2025) Simultaneous editing of SPO11-1, REC8 and OSD1 yields aneutetraploid soybeans. Plant Biotechnology Journal 23: 3757-3759.

8. Bennett MJ#, Bhosale R, Boden SA#, Chen S-Y, Colombi T, Ito T#, Li HJ#, Mehra P, Østergaard L#, Li M, Liu L, Otsuka N, Pandey BK, Poethig S#, Prasad K, Qu Y, Shirakawa M, Su YH#, Xu C#, Yang WC#, Zhang WJ, Zhang XL#, Zhang XS#, Zhou ZY, Wu S# (2025) Developmental pathways in plants: Lessons from Arabidopsis for crop innovation. Plant Cell 37: koaf136.

9. Zhang CB#, Yang X, Chen S-Y, Li HJ# (2025) Utilization of hybrid vigor in soybean: challenges and innovative avenues. Chinese Science Bulletin 70: 3084-3100.

10. Sun SN, Jia PF, Wang W, Chen LC, Gong XR, Lin HF, Wu R, Yang WC, Li HJ, Zuo J, Guo HY (2025) S-Sulfenylation-mediated inhibition of the GSNOR1 activity regulates ovule development in Arabidopsis. Journal of Genetics and Genomics 52: 1034-1045.

11. Sugi N, Calhau ARM, Jacquier NMA, Millan-Blanquez M, Becker JD, Begcy K, Berger F, Bousquet-Antonelli C, Bouyer D, Cai G, Cheung AY, Coimbra S, Denninger P, Dresselhaus T, Feijó JA, Fowler JE, Geelen D, Grossniklaus U, Higashiyama T, Honys D, Igawa T, Ingram G, Jaillais Y, Johnson MA, Kato M, Kawachi M, Kawashima T, Kim YJ, Li HJ, Mongrand S, Motomura K, Nagahara S, Nakajima KP, Nelms B, Qu LJ, Schnittger A, Scholten S, Sprunck S, Sun MX, Twell D, Weijers D, Yang WC, Maruyama D#, Widiez T# (2024) The peri-germ cell membrane: poorly characterized but key interface for plant reproduction. Nature Plants 10: 1607-1609.

12. Chen WQ, Xu LP, Rao YC, Liu CL, Hong ZY, Lu HW, Liu CM, Li HJ#, Wang KJ# (2024) Self-propagated clonal seed production in dicotyledonous Arabidopsis. Science Bulletin 3: S2095-9273.

13. Chen S-Y, Li HJ (2024) Paternal protection of offspring organogenesis. Seed Biology 3: e016.

14. Cao MX*, Li SZ*, Li HJ (2024) MpMLO1 controls sperm discharge in liverwort. Nature Plants 10: 1027–1038.

15. Meng JG, Li SZ, Li HJ (2024) Central cell: the key to determine persistent pollen tube attraction or termination. Science China Life Sciences 67:2030-2032.

16. Xu YJ*, Luo T*, Zhou PM*, Wang WQ, Yang WC, Li HJ (2024) Pollen-expressed RLCKs control pollen tube burst. Plant Communications 5: 100934.

17. Wang WQ*, Meng JG*, Yang F, Xu YJ, Li SZ, Li HJ (2024) A non-defensin peptide NPA1 attracts pollen tube in Arabidopsis. Seed Biology 3: e003.

18. Zhong S*, Zhao P*, Peng XB*, Li HJ*, Duan QH*, Cheung AY (2024) From gametes to zygote: mechanistic advances and emerging possibilities in plant reproduction. Plant Physiology 195: 4-35.

19. Meng JG*, Xu YJ*, Wang WQ*, Yang F*, Chen S-Y, Jia PF, Yang WC, Li HJ (2023) Central cell-produced attractants control fertilization recovery. Cell 186: 3593-3605.

20. Wang J, Wang XF, Yang WC#, Li HJ# (2023) Loss of function of CENH3 causes genome instability in soybean. Seed Biology 2: 24.

21. Li SZ, Wang J, Jia SG, Wang KJ#, Li HJ# (2023) Synthetic apomixis: from genetic basis to agricultural application. Seed Biology 2: 10.

22. Chen S-Y, Wang L, Jia PF, Yang WC, Sze H, Li HJ (2022) Osmoregulation determines sperm cell geometry and integrity for double fertilization in flowering plants. Molecular Plant 15: 1488–1496.

23. Xue Y*, Meng JG*, Jia PF, Zhang ZR, Li HJ#, Yang WC# (2022) POD1-SUN-CRT3 chaperone complex guards the ER sorting of LRR receptor kinases in Arabidopsis. Nature Communications 13: 2703.

24. Xue Y, Jia PF, Li HJ (2022) SUN3/4/5 proteins regulate endoplasmic reticulum tubule formation and luminal spacing in Arabidopsis. Journal of Genetics and Genomics 50: 370-373.

25. Luo Y, Shi DQ, Jia, PF, Bao Y, Li HJ, Yang WC (2021) Nucleolar histone deacetylases HDT1, HDT2 and HDT3 regulate plant reproductive development. Journal of Genetics and Genomics 49: 30-39.

26. Li HJ#, Yang WC# (2020) Central cell in flowering plants: specification, signaling, and evolution. Frontiers Plant Science 11: 590307.

27. Chen W, Jia PF, Yang WC#, Li HJ# (2020) Plasma membrane H⁺-ATPases-mediated cytosolic proton gradient regulates pollen tube growth. Journal of Integrative Plant Biology 62: 1817-1822.

28. Zhang MX#, Zhu SS#, YC, Guo YL, Yang WC#, Li HJ# (2020) Transcriptional repression specifies the central cell for double fertilization. Proc Natl Acad Sci U S A 117: 6231-6236.

29. Meng JG#, Liang L#, Jia PF, Wang YC, Li HJ#, Yang WC# (2020) Integration of ovular signals and exocytosis of a Ca²⁺channel by MLOs in pollen tube guidance. Nature Plants 6: 143-153.

30. Meng JG, Zhang MX, Yang WC#, Li HJ# (2019) TICKET attracts pollen tubes and mediates reproductive isolation between relative species in Brassicaceae. Science China Life Sciences 62: 1413-1419.

31. Shi C, Luo P, Du YT, Chen H, Huang X, Cheng TH, Luo A, Li HJ, Yang WC, Zhao P, Sun MX (2019) Maternal control of suspensor programmed cell death via gibberellin signaling. Nature Communications 10: 3484.

32. Jia PF*, Xue Y*, Li HJ#, Yang WC# (2018) Golgi-localized LOT regulates trans-Golgi network biogenesis and pollen tube growth. Proc Natl Acad Sci U S A 115: 12307-12312.

33. Li HJ#, Meng JG, Yang WC# (2018) Multilayered signaling pathways for pollen tube growth and guidance. Plant Reproduction 31: 31-41.

34. Li HJ#, Yang WC# (2018) Ligands switch model for pollen-tube integrity and burst. Trends in Plant Science 23: 369-372.

35. Yuan GL, Li HJ#, Yang WC# (2017) The integration of Gβ and MAPK signaling cascade in zygote development. Scientific Reports 7: 8732.

36. Jia PF, Li HJ, Yang WC (2017) Analysis of peroxisome biogenesis in pollen by confocal microscopy and transmission electron microscopy. Methods in Molecular Biology 1669:173-180. Springer.

37. Jia PF, Li HJ, Yang WC (2017) Transmission electron microscopy (TEM) to study histology of pollen and pollen tubes. Methods in Molecular Biology 1669: 181-189. Springer.

38. Wang T, Liang L, Yong X, Jia PF, Chen W, Zhang MX, Wang YC, Li HJ#, Yang WC# (2016) A receptor heteromer mediates the male perception of female attractants in plants. Nature 531: 241-244.

39. Li HJ#, Yang WC# (2016) RLKs orchestrate the signaling in plant male-female interaction. Science China Life Sciences 59: 867-877.

40. Wang JG, Feng C, Liu HH, Ge FR, Li S, Li HJ, Zhang Y (2016) HAPLESS13-mediated trafficking of STRUBBELIG is critical for ovule development in Arabidopsis. PLoS Genetics 12: e1006269.

41. Yu TY, Shi DQ, Jia PF, Tang J, Li HJ, Liu J, Yang WC (2016). The Arabidopsis receptor kinase ZAR1 is required for zygote asymmetric division and its daughter cell fate. PLoS Genetics 12: 0-e1005933.

42. Wang JZ*, Li HJ*, Han ZF, Zhang HQ, Wang T, Lin GZ, Chang JB, Yang WC#, Chai JJ# (2015) Allosteric receptor activation by the plant peptide hormone phytosulfokine. Nature 525: 265-268.

43. Li HJ*, Zhu SS*, Zhang MX*, Wang T, Liang L, Xue Y, Shi DQ, Liu J, Yang WC (2015) Arabidopsis CBP1 is a novel regulator of transcription initiation in central cell-mediated pollen tube guidance. Plant Cell 27: 2880-2893.

44. Yan LH, Wei SW, Wu YR, Hu RL, Li HJ, Yang WC, Qi Xie (2015) High efficiency genome editing in Arabidopsis using Yao promoter-driven CRISPR/Cas9 system. Molecular Plant 1823: 1820-1823.

45. Li XR*, Li HJ*, Yuan L*, Liu M, Shi DQ, Liu J, Yang WC (2014) Arabidopsis DAYU/ABERRANT PEROXISOME MORPHOLOGY9 is a key regulator of peroxisome biogenesis and plays critical roles during pollen maturation and germination in planta. Plant Cell 26: 619-635.

46. Li HJ, Yang WC (2012) Emerging role of ER quality control in plant cell signal perception. Protein Cell 3: 10-16.

47. Li HJ, Xue Y, Jia DJ, Wang T, Shi DQ, Liu J, Cui F, Xie Q, Ye D, Yang WC (2011) POD1 regulates pollen tube guidance in response to micropylar female signaling and acts in early embryo patterning in Arabidopsis. Plant Cell 23: 3288-3302.

48. Li HJ*, Liu NY*, Shi DQ, Liu J, Yang WC (2010) YAO is a nucleolar WD40-repeat protein critical for embryogenesis and gametogenesis in Arabidopsis. BMC Plant Biology 10: 169.

49. Chen YH, Li HJ, Shi DQ, Yuan L, Liu J, Sreenivasan R, Baskar R, Grossniklaus U, Yang WC (2007) The central cell plays a critical role in pollen tube guidance in Arabidopsis. Plant Cell 19: 3563-3577.